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The production of barium sulfate involves several stages, including mining, beneficiation, and processing. The first step is to extract barium sulfate from the earth, which is typically done through underground or open-pit mining methods. Once the ore is extracted, it undergoes beneficiation to separate the barium sulfate from other impurities. This process may include washing, grinding, and flotation techniques.

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At the present JECFA meeting, the committee considered additional toxicological studies relevant to the safety assessment of the chemical that investigated its toxicokinetics, acute toxicity, short-term toxicity, long-term toxicity and carcinogenicity, genotoxicity, and reproductive and developmental toxicity, as well as special studies addressing its short-term initiation/promotion potential for colon cancer. The experts acknowledged that a large number of toxicological studies have been conducted using test materials, including nanoparticles, having size distributions and physico-chemical properties not comparable to real-world uses of titanium dioxide as a food additive. The studies on non-representative materials were evaluated by JECFA, but the committee concluded that such studies are not relevant to the safety assessment of the additive.

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